Better protection from meningococcal disease - Sheffield

The HBP1 protein as a candidate vaccine for meningococcal disease

University of Sheffield Research 2
Background

In order to cause serious disease, meningococcal bacteria need to be able to move from the back of the throat into the bloodstream and spread around the body. These bacteria need iron to survive, and in the bloodstream the source of iron is either heme or haemoglobin. The researchers have identified a protein produced by meningococcal bacteria that allows them to use these sources of iron in the bloodstream. The protein is called heme binding protein 1 (HBP1). Earlier experiments have indicated that this protein may be useful in a vaccine to protect against meningococcal disease.

What the researchers did

The researchers first checked to see whether most meningococcal bacteria actually have the gene that makes HBP1 and found that they all do, but some make a slightly different version. They prepared samples of these different versions and found that antibodies raised against one HBP1 version were able to recognise all the different versions tested. They also found that the antibodies were able to activate components of human blood, allowing killing of the meningococcal bacteria.

The difference this could make

The results of this project could lead to the development of a vaccine offering broader protection against meningococcal disease and could also be applied to protection against other infectious diseases.

Outcome

The project was completed in November 2013 and the researchers are keen to continue the investigation of this potential vaccine candidate. They have filed a patent application and are in discussion with the venture capital sector.

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Researchers

Professor Jon Sayers, Professor Andrew Heath, Professor Robert Read

Research Institution

University of Sheffield

More information

If you would like more information about this project, or our research in general, please contact Jane on JaneB@meningitisnow.org