Two important studies show the positive impact of MenACWY vaccine in teenagers

The findings, published in Clinical Microbiology and Infection, have demonstrated the impact of the vaccine in generating herd protection, also called herd immunity, that protects all age groups.

Researchers from the University of Oxford took throat swabs and assessed the prevalence of meningitis causing bacteria before and after the introduction of the vaccination programme, using two cross-sectional studies conducted almost four years apart. They found the vaccine substantially reduced carriage of the W and Y meningococcal groups, and sustained low levels of the C group.

In 2015, responding to rising rates of meningitis cases driven by the W and Y strains from 2009 onwards, the UK replaced a vaccine targeting only the C group (introduced in 1999) with quadrivalent MenACWY vaccines. To leverage herd immunity effects, the vaccination programme targeted teenagers aged 14 to 19, where transmission of the meningococcal bacteria is known to be highest.

Enthusiasm for research

One of the lead authors, Matthew Snape, Professor in Paediatrics and Vaccinology at the Oxford Vaccine Group, University of Oxford, said:

“These studies report the results of throat swabs taken from over 24,000 teenagers in more than 170 secondary schools across the country, showing yet again the fantastic enthusiasm of the UK public for taking part in research.

“The results show us that by immunising teenagers with MenACWY vaccines we not only protect them directly, but also reduce the risk of all others in the community suffering from meningitis and sepsis due to these bacteria.

“Immunising teenagers rather than infants means we get more benefit out of each dose given. These two studies therefore provide invaluable data to help us use these vaccines effectively, both in the UK and internationally.”

Two studies

The researchers compared two studies – the UKMenCar4 study, conducted between September 2014 and March 2015 before the MenACWY vaccine was introduced, and the Be on the TEAM study, conducted between March 2018 and November 2018 after the vaccine was introduced. We helped recruit teenagers for the Be on the TEAM study.

Data from 24,062 students aged 15 to 19 were included: 10,624 from UKMenCar4 and 13,428 from Be on the TEAM. The researchers concluded:

• C, W, and Y meningococcal carriage decreased from 2.03% to 0.71%;
• carriage of the W group decreased from 0.34% to 0.09%;
• carriage of the Y group decreased from 1.6% to 0.5%; and
• carriage of the C group remained rare (0.07% to 0.13%)

MenW down in all age groups

The findings align with data from the UKHSA showing that the incidence of MenW disease has fallen in all age groups since the teenage MenACWY vaccine campaign; not just in teenagers themselves. Taken together these data provide strong evidence for the need to target age groups with high rates of meningococcal transmission to make most effective use of these vaccines, and not necessarily immunising other age groups at high risk (such as infants), add the researchers.

Martin Maiden, Professor of Molecular Epidemiology at the Department of Biology, University of Oxford, lead author on the paper said:

“We have been systematically investigating meningococcal vaccination and its effects on carriage in Oxford since 1999. These studies have been crucial in enabling the most effective use of meningococcal vaccines around the world. 

“In combination with our work with colleagues at Public Health England (now HSA) that characterised the MenW epidemic variant at the genomic level, this work helped to interrupt an epidemic that would likely have affected thousands of individuals. This demonstrates the importance of long-term studies that permit the anticipation of epidemics and pandemics and enables them to be curtailed before they impact the population too severely.”

Pleased to be on the TEAM

Our chief executive, Dr Tom Nutt, said: “We were pleased to play a part in this vital Be on the TEAM research. As we know only too well, meningitis is a devastating disease that can strike anyone at any time and leave havoc in its wake. Many young people will know of someone from their community whose life, and that of their family and friends, has been torn apart by its impact. 

“We’re delighted to see that this important study has demonstrated such positive results for not just young people’s health but across the wider community too. 

“Now we need to redouble our efforts to encourage all those who are eligible for their free MenACWY vaccination to take advantage of it.”

Professor Nick Lemoine of the National Institute for Health and Care Research (NIHR) said: ‘This NIHR-supported study has provided important data on the effectiveness of MenACWY vaccines in inducing population immunity against meningitis - which has been shown to protect all ages against this potentially life-threatening disease. We want to thank the incredible 24,000 teenage participants who took part for their contributions.’

Public Health and Mental Health Minister Dr Caroline Johnson added: “This study shows why the MenACWY vaccination programme is so important, allowing young people to protect themselves and in turn all age groups from this potentially life-threatening disease.

“Vaccination remains the best line of defence against infectious diseases, including meningitis, and I encourage everyone eligible to take up their free jab.”

The study was funded by the Wellcome Trust and the National Institute for Health Research (NIHR) Policy Research Programme.